The results of NSAID alone or with physical exercise (physiotherapy) were not associated with improvement in pain and function compared with the injection of hyaluronic acid. Ozone injection showed no improvement in pain and function at 12 months. Ozone injection is the only intervention for which knee pain and/or function got worse at the end of the study compared with the baseline. Corticosteroid improved outcomes but did not perform better than the control or placebo. Mesenchymal stem cells and PRP were significantly better than the chosen control (placebo) and associated with improvement in knee status. Using a primary outcome scoring system – the WOMAC or Western Ontario and McMaster Universities Osteoarthritis Index, universally used by health professionals to evaluate the condition of knee osteoarthritis patients), these are the findings: The authors wrote: “The interventions had different effects on the participants suffering from knee osteoarthritis.” How? Administration of nonsteroidal anti-inflammatory drugs with physical therapy. Administration of nonsteroidal anti-inflammatory drugs,. Mesenchymal stem cells (MSCs), Mesenchymal stem cells are injected into a damaged joint and surrounding area, of stem cells drawn from the patient’s own bone marrow. I discuss Platelet Rich Plasma (PRP) further below. The collected platelets and their healing elements are then injected back into the injured area to stimulate healing and regeneration. PRP treatments involve collecting a small amount of your blood and spinning it in a centrifuge to separate the platelets from the red cells. The authors wrote that their goal was to “find out, based on the available recent randomized controlled trials (RCTs), if the nonsurgical interventions commonly used for knee osteoarthritis patients are valid and quantify their efficiency (prove their effectivness).” The treatments assessed were: Seven different knee osteoarthritis treatmentsĪ December 2021 study ( 1) assessed seven different knee osteoarthritis treatments. In the research below various comparisons are made between the different types of knee injections. Most want to know “which works the best?” Let’s have researchers answer that question. These people come to see us because they are exploring non-surgical alternatives and have investigated various types of knee injections. doi:10.Many patients we see have been researching their options in managing their chronic knee pain. Aspiration and injection of the knee joint: approach portal. Effects of botulinum toxin landmark-guided intra-articular injection in subjects with knee osteoarthritis. Human amniotic membrane intra-articular injection prevents cartilage damage in an osteoarthritis model. Marino-Martínez IA, Martínez-Castro AG, Peña-Martínez VM, Acosta-Olivo CA, Vílchez-Cavazos F, Guzmán-López A, Pérez Rodríguez E, Romero-Díaz VJ, Ortega-Blanco JA, Lara-Arias J. 4 Injections That Could Ease Your Joint Pain. Intra-articular injections of platelet-rich plasma, hyaluronic acid or corticosteroids for knee osteoarthritis : A prospective randomized controlled study. Viscosupplementation Treatment for Knee Arthritis. doi: 10.1186/s1289-0Īmerican Academy of Orthopedic Surgeons. Osteoarthritis- a systematic review of long-term safety implications for osteoarthritis of the knee. doi: 10.1002/acr.24131Ĭharlesworth J, Fitzpatrick J, Perera NKP, Orchard J. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. 
Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guyatt G, Block J, Callahan L, Copenhaver C, Dodge C, Felson D, Gellar K, Harvey WF, Hawker G, Herzig E, Kwoh CK, Nelson AE, Samuels J, Scanzello C, White D, Wise B, Altman RD, DiRenzo D, Fontanarosa J, Giradi G, Ishimori M, Misra D, Shah AA, Shmagel AK, Thoma LM, Turgunbaev M, Turner AS, Reston J. Therapeutic Injections for Osteoarthritis of the Knee.
Knee osteoarthritis has doubled in prevalence since the mid-20th century. Wallace IJ, Worthington S, Felson DT, et al.
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